Emerging infectious diseases do not respect the boundaries between people, animals and the environment. To mark International One Health Day, Stellenbosch University's Centre for Epidemic Response and Innovation (CERI) and the University of Pretoria bring together leading voices from government, research and veterinary science to examine how a One Health approach strengthens South Africa's preparedness. Topics: - One Health implementation and the role of animal health - Tuberculosis at the human–wildlife interface - Spillover prevention - Arbovirus surveillance